USC-OGP 2-DE database Two-dimensional polyacrylamide gel electrophoresis database

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Searching in 'USC-OGP 2-DE database' for entry matching: P48637 USC-OGP 2-DE database:  P48637 P48637 General information about the entry View entry in simple text format Entry name GSHB_HUMAN Primary accession number P48637 integrated into USC-OGP 2-DE database on  January 17, 2017 (release 1) 2D Annotations were last modified on January 17, 2017 (version 1) General Annotations were last modified on  April 5, 2017 (version 2) Name and origin of the protein Description RecName: Full=Glutathione synthetase; Short=GSH synthetase; Short=GSH-S; EC=6.3.2.3; AltName: Full=Glutathione synthase;. Gene name Name=GSS Annotated species Homo sapiens (Human) [TaxID: 9606] Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. References [1]   2D GEL CHARACTERIZATION Author 1., Author 2. Submitted (Mar-2011) to Current 2D PAGE maps for identified proteins How to interpret a protein PLATELET_4-7 {PLATELET 4-7} Homo sapiens (Human)   map experimental info   PLATELET_4-7 MAP LOCATIONS: SPOT OGP-0365: pI=5.45; Mw=50591 SPOT OGP-0468: pI=5.54; Mw=31889 PLATELET_5-6 {PLATELET 5-6} Homo sapiens (Human)   map experimental info   PLATELET_5-6 MAP LOCATIONS: SPOT OGP-0668: pI=5.45; Mw=51565 Cross-references UniProtKB/Swiss-Prot P48637; GSHB_HUMAN. 2D PAGE maps for identified proteins How to interpret a protein map You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw. Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly. Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed. External data extracted from UniProtKB/Swiss-Prot Extracted from UniProtKB/Swiss-Prot, release: 0.0 Entry name GSHB_HUMAN Primary accession number P48637 Secondary accession number(s) B2R697 B6F210 E1P5P9 Q4TTD9 Sequence was last modified on  February 1, 1996 (version 1) Annotations were last modified on  March 15, 2017 (version 175) Name and origin of the protein Description RecName: Full=Glutathione synthetase; Short=GSH synthetase; Short=GSH-S; EC=6.3.2.3; AltName: Full=Glutathione synthase; Gene name Name=GSS Encoded on Name=GSS Keywords 3D-structure; Acetylation; Alternative splicing; ATP-binding; Complete proteome; Direct protein sequencing; Disease mutation; Glutathione biosynthesis; Hereditary hemolytic anemia; Ligase; Magnesium; Metal-binding; Nucleotide-binding; Phosphoprotein; Polymorphism; Reference proteome. Copyright Copyrighted by the UniProt Consortium, see http://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License Cross-references EMBL L42531; AAA69492.1; -; mRNA EMBL AB459500; BAG75452.1; -; mRNA EMBL U34683; AAB62390.1; -; mRNA EMBL AK312492; BAG35394.1; -; mRNA EMBL DQ074975; AAY57328.1; -; Genomic_DNA EMBL AL133324; CAB93423.1; -; Genomic_DNA EMBL CH471077; EAW76239.1; -; Genomic_DNA EMBL CH471077; EAW76240.1; -; Genomic_DNA EMBL BC007927; AAH07927.1; -; mRNA CCDS CCDS13245.1; -. [P48637-1]; . PIR S56748; S56748; . RefSeq NP_000169.1; NM_000178.3. [P48637-1]; . RefSeq NP_001309423.1; NM_001322494.1. [P48637-1]; . RefSeq NP_001309424.1; NM_001322495.1. [P48637-1]; . UniGene Hs.82327; -; . PDB 2HGS; X-ray; 2.10 A; A=1-474 PDBsum 2HGS; -; . ProteinModelPortal P48637; -; . SMR P48637; -; . BioGrid 109192; 27; . IntAct P48637; 3; . MINT MINT-5001027; -; . STRING 9606.ENSP00000216951; -; . DrugBank DB06151; Acetylcysteine; . DrugBank DB03408; gamma-Glutamylcysteine; . DrugBank DB00143; Glutathione; . DrugBank DB00145; Glycine; . DrugBank DB00151; L-Cysteine; . DrugBank DB04395; Phosphoaminophosphonic Acid-Adenylate Ester; . iPTMnet P48637; -; . PhosphoSitePlus P48637; -; . BioMuta GSS; -; . DMDM 1346191; -; . OGP P48637; -; . REPRODUCTION-2DPAGE IPI00010706; -; . EPD P48637; -; . PaxDb P48637; -; . PeptideAtlas P48637; -; . PRIDE P48637; -; . DNASU 2937; -; . Ensembl ENST00000216951; ENSP00000216951; ENSG00000100983. [P48637-1]; . Ensembl ENST00000451957; ENSP00000407517; ENSG00000100983. [P48637-2]; . GeneID 2937; -; . KEGG hsa:2937; -; . UCSC uc010zuo.3; human. [P48637-1]; . CTD 2937; -; . DisGeNET 2937; -; . GeneCards GSS; -; . HGNC HGNC:4624; GSS; . HPA HPA054508; -; . HPA HPA059315; -; . MalaCards GSS; -; . MIM 231900; phenotype; . MIM 266130; phenotype; . MIM 601002; gene; . neXtProt NX_P48637; -; . OpenTargets ENSG00000100983; -; . Orphanet 289846; Glutathione synthetase deficiency with 5-oxoprolinuria; . Orphanet 289849; Glutathione synthetase deficiency without 5-oxoprolinuria; . PharmGKB PA29015; -; . eggNOG KOG0021; Eukaryota; . eggNOG ENOG410XPHH; LUCA; . GeneTree ENSGT00390000013764; -; . HOGENOM HOG000172641; -; . HOVERGEN HBG002458; -; . InParanoid P48637; -; . KO K01920; -; . OMA YMPRQYS; -; . OrthoDB EOG091G05V8; -; . PhylomeDB P48637; -; . TreeFam TF105187; -; . BioCyc MetaCyc:HS02174-MONOMER; -; . BRENDA 6.3.2.3; 2681; . Reactome R-HSA-174403; Glutathione synthesis and recycling; . SABIO-RK P48637; -; . UniPathway UPA00142; UER00210; . ChiTaRS GSS; human; . EvolutionaryTrace P48637; -; . GenomeRNAi 2937; -; . PRO PR:P48637; -; . Proteomes UP000005640; Chromosome 20; . Bgee ENSG00000100983; -; . CleanEx HS_GSS; -; . ExpressionAtlas P48637; baseline and differential; . Genevisible P48637; HS; . GO GO:0005829; C:cytosol; TAS:Reactome; . GO GO:0070062; C:extracellular exosome; IDA:UniProtKB; . GO GO:0005524; F:ATP binding; IDA:UniProtKB; . GO GO:0043295; F:glutathione binding; IDA:UniProtKB; . GO GO:0004363; F:glutathione synthase activity; TAS:Reactome; . GO GO:0016594; F:glycine binding; IEA:Ensembl; . GO GO:0042802; F:identical protein binding; IPI:IntAct; . GO GO:0000287; F:magnesium ion binding; IDA:UniProtKB; . GO GO:0042803; F:protein homodimerization activity; IDA:UniProtKB; . GO GO:0007568; P:aging; IEA:Ensembl; . GO GO:0006520; P:cellular amino acid metabolic process; TAS:ProtInc; . GO GO:0006750; P:glutathione biosynthetic process; TAS:Reactome; . GO GO:0007399; P:nervous system development; TAS:ProtInc; . GO GO:0043200; P:response to amino acid; IEA:Ensembl; . GO GO:0046686; P:response to cadmium ion; IEA:Ensembl; . GO GO:0031667; P:response to nutrient levels; IEA:Ensembl; . GO GO:0006979; P:response to oxidative stress; TAS:ProtInc; . GO GO:0034612; P:response to tumor necrosis factor; IEA:Ensembl; . GO GO:0009410; P:response to xenobiotic stimulus; IEA:Ensembl; . CDD cd00228; eu-GS; 1; . Gene3D 1.10.1080.10; -; 2; . Gene3D 3.30.1490.50; -; 1; . Gene3D 3.30.1490.80; -; 2; . Gene3D 3.40.50.1760; -; 1; . InterPro IPR004887; Glutathione_synth_subst-bd_euk; . InterPro IPR005615; Glutathione_synthase; . InterPro IPR014042; Glutathione_synthase_a-hlx_euk; . InterPro IPR014709; Glutathione_synthase_dom; . InterPro IPR014049; Glutathione_synthase_N_euk; . InterPro IPR016185; PreATP-grasp_dom; . PANTHER PTHR11130; PTHR11130; 1; . Pfam PF03917; GSH_synth_ATP; 1; . Pfam PF03199; GSH_synthase; 1; . PIRSF PIRSF001558; GSHase; 1; . SUPFAM SSF52440; SSF52440; 1; . TIGRFAMs TIGR01986; glut_syn_euk; 1; .

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